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Core EM - Emergency Medicine Podcast


Core EM - Emergency Medicine Podcast

Episode 202: Sexually Transmitted Infections 2.0

Fri, 01 Nov 2024




We review Sexually Transmitted Infections and pertinent updates in diagnosis and management.


Hosts:

Avir Mitra, MD

Brian Gilberti, MD






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Show Notes


Table of Contents


(1:49) Chlamydia 


(3:31) Gonorrhea


(4:50) PID


(6:14) Syphilis


(8:08) Neurosyphilis 


(9:13) Tertiary Syphilis


(10:06) Trichomoniasis 


(11:13) Herpes


(12:49) HIV


(14:10) PEP


(15:13) Mycoplasma Genitalium 


(18:00) Take Home Points




Chlamydia:



  • Prevalence:







      • Most common STI.

      • High percentage of asymptomatic cases (40% to 96%).







  • Presentation:







      • Urethritis, cervicitis, pelvic inflammatory disease (PID), prostatitis, proctitis, pharyngitis, arthritis.

      • Importance of considering extra-genital sit...

Episode 201: Migraines

Tue, 01 Oct 2024




We discuss migraines with one of the authorities in the field.


Hosts:

Benjamin Friedman, MD of Montefiore

Brian Gilberti, MD






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Show Notes


Initial Approach to Diagnosing Migraines:



  • Differentiating between primary headaches (migraine, tension-type, cluster) and secondary causes (e.g., subarachnoid hemorrhage).

  • The importance of patient history and reevaluation after initial treatment.

  • Recognizing the unique presentation of cluster headaches and their management implications.


Effective Acute Migraine Treatments:



  • First-line treatments including anti-dopaminergic medications like metoclopramide (Reglan) and prochlorperazine (Compazine), and parenteral NSAIDs like ketorolac (Toradol).

  • The limited role of triptans in the ED due to side effects and less efficacy compared to anti-dopaminergics.

  • The use of nerve blocks (greater occipital nerve block and sphenopalatine ganglion block) as effective treatments without systemic side effects.


Treatments to Avoid or Use with Caution:



  • Diphenhydramine (Benadryl): Studies show it does not prevent akathisia from anti-dopaminergics nor improve migraine outcomes.

  • IV Fluids: Routine use is not supported unless the patient shows signs of dehydration.

  • Magnesium: Conflicting evidence with some studies showing no benefit or even harm.


Managing Refractory Migraines:



  • Second-line treatments including additional doses of metoclopramide combined with NSAIDs or dihydroergotamine (DHE).

  • Considering opioids as a last resort when other treatments fail.

Episode 200: Immune Checkpoint Inhibitors

Mon, 02 Sep 2024




We discuss a new class of medications, Immune Checkpoint Inhibitors, and their side effects.


Hosts:

Avir Mitra, MD

Brian Gilberti, MD






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Show Notes


Overview of Immune Checkpoint Inhibitors (ICIs)



  • ICIs are a relatively new class of oncologic drugs that have revolutionized cancer treatment.

  • Unlike chemotherapy, ICIs help the immune system develop memory against cancer cells and adapt as the cancer mutates.

  • Since their release in 2011, ICIs have expanded to 83 indications for 17 different cancers, with approximately 230,000 patients using them.


Mechanism of Action



  • Cancer cells can evade the immune system by binding to T cell receptors that downregulate the immune response.

  • ICIs work by blocking these receptors or ligands, preventing the downregulation and allowing T cells to proliferate and attack cancer cells.

  • Common ICIs


Risks and Toxicities of ICIs



  • ICIs can lead to autoimmune attacks on healthy cells due to immune system upregulation.

Episode 199: Ataxia in Children

Thu, 01 Aug 2024




We discuss a case of ataxia in children and how to approach the evaluation of these pts.


Hosts:

Ellen Duncan, MD, PhD

Brian Gilberti, MD






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Show Notes


Introduction



  • The episode focuses on ataxia in children, which can range from self-limiting to life-threatening conditions.

  • Pediatric emergency medicine specialist shares insights on the topic.


The Case



  • An 18-month-old boy presented with ataxia, unable to keep his head up, sit, or stand, and began vomiting.

  • Previously healthy except for recurrent otitis media and viral-induced wheezing.

  • The decision to take the child to the emergency department (ED) was based on acute symptoms.


Differential Diagnosis



  • Common causes include acute cerebellar ataxia, drug ingestion, Guillain-Barre syndrome, and basilar migraine.

  • Less common causes include cerebellitis, encephalitis, brain tumors, and labyrinthitis.


Importance of History and Physical Examination



  • A detailed history and physical exam are essential in diagnosing ataxia.

  • Key factors include time course, recent infections, signs of increased intracranial pressure, and toxic exposures.

  • Look for signs such as bradycardia, hypertension, vomiting, and overall appearance.


Diagnostic Workup



  • Initial tests include point-of-care glucose and neuroimaging for concerns about trauma or increased intracranial pressure.

  • MRI is preferred for posterior fossa abnormalities,

Episode 198: Hypernatremia

Mon, 01 Jul 2024




We discuss the approach to diagnosing and managing hypernatremia in the emergency department.


Hosts:

Abigail Olinde, MD

Brian Gilberti, MD






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Show Notes


Episode Overview:



  • Introduction to Hypernatremia

  • Definition and basic concepts

  • Clinical presentation and risk factors

  • Diagnosis and management strategies

  • Special considerations and potential complications


Definition and Pathophysiology:



  • Hypernatremia is defined as a serum sodium level over 145 mEq/L.

  • It can be acute or chronic, with chronic cases being more common.

  • Symptoms range from nausea and vomiting to altered mental status and coma.


Causes of Hypernatremia based on urine studies:



  • Urine Osmolality > 700 mosmol/kg

    • Causes:

      • Extrarenal Water Losses: Dehydration due to sweating, fever, or respiratory losses

      • Unreplaced GI Losses: Vomiting, diarrhea

      • Unreplaced Insensible Losses: Burns, extensive skin diseases

      • Renal Water Losses with Intact AVP Response:

      • Diuretic phase of acute kidney injury

      • Recovery phase of acute tubular necrosis

      • Postobstructive diuresis





  • Urine Osmolality 300-600 mosmol/kg

    • Causes:

      • Osmotic Diuresis: High glucose (diabetes mellitus), mannitol, high urea

      • Partial AVP Deficiency: Incomplete central diabetes insipidus

      • Partial AVP Resistance: Nephrogenic diabetes insipidus





  • Urine Osmolality < 300 mosmol/kg

    • Causes:

      • Complete AVP Deficiency: Central diabetes insipidus

      • ...

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